Sweden is the most important producer of Zn and Pb and the second largest producer of Ag in the EU28. These metals are mainly produced from metamorphosed and deformed Palaeoproterozoic massive sulphide deposits in Skellefte and Bergslagen mining districts. This short course provides and overview of the tectonic setting of these deposits including their regional structural and stratigraphic context, key deposit characteristics and exploration history. A strong overprint by the c. 1.9-1.8 Ga Svecokarelian orogeny still present a considerable challenge to both ore genetic studies and exploration activities. Much of the exploration success during the last 100 years has resulting from an interplay between conceptual geological modeling, technological innovation and entrepreneurship. The short course will also review some of these success stories.